the effects of topical sildenafil on wound healing in rat

نویسندگان

akram jamshidzadeh

department of pharmacology and toxicology and pharmaceutical research center, faculty of pharmacy, shiraz university of medical sciences, shiraz, iran. negar azarpira

transplant research center, nemazi hospital, shiraz university of medical sciences, shiraz, iran.

چکیده

nitric oxide (no) is an important molecule synthesized during wound repair. studies have reported the use of no donors on cutaneous wound repair, but their effects in different phases of healing are not elucidated. the aim of this work was to investigate the effects of topical sildenafil on wounds in rats. sildenafil (25 mg) was topically applied once daily on wound in treatment groups. on days, 7, 14 and 21 of lesion, five animals in each group were randomly selected and sacrificed and histological properties were evaluated. our results showed the wound area contracted to 15% of the original size by day 7 post-wounding in treated group. whereas control rats showed significantly delayed wound healing. the wound area contracted to 26% of the original size by day 14 post-wounding and to 46% by day 21 post-wounding. also sildenafil cream caused more fibroblast and macrophage migration, increased vascularization, collagen regeneration, and epithelialization. this study indicates that sildenafil cream augments the wound healing process and may be of clinical benefit.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effects of Topical Sildenafil on Wound Healing in Rat

     Nitric oxide (NO) is an important molecule synthesized during wound repair. Studies have reported the use of NO donors on cutaneous wound repair, but their effects in different phases of healing are not elucidated. The aim of this work was to investigate the effects of topical sildenafil on wounds in rats. Sildenafil (25 mg) was topically applied once daily on wound in treatment groups. On...

متن کامل

The Effects of Pentoxifylline on the Wound Healing Process in a Rat Experimental Pressure Sore Model

Introduction: The present study used a histological evaluation method to examine the effects of pentoxifylline (PTX) on healing an experimentally-induced pressure sore in a rat model. Materials and Methods: There were 36 adult male rats used in this study. Under general anesthesia and sterile conditions, we used forceps to create one pressure sore on each rat. A double layer of folded skin...

متن کامل

the effects of changing roughness on the flow structure in the bends

flow in natural river bends is a complex and turbulent phenomenon which affects the scour and sedimentations and causes an irregular bed topography on the bed. for the reason, the flow hydralics and the parameters which affect the flow to be studied and understand. in this study the effect of bed and wall roughness using the software fluent discussed in a sharp 90-degree flume bend with 40.3cm ...

Effects of Topical Application of Royal Jelly on Second-Degree Burn Wound Healing in Male Rats

Background and Aims: Burn injury remain as a major medical problem throughout the world. This injury is accompanied with inflammatory and wound healing responses. Since royal jelly (RJ) has anti-inflammatory and wound healing activity therefore, the aim of this study was to evaluate the repairing effects of RJ on skin burn- damage. Materials and Methods: In an experimental study, 40 male Wista...

متن کامل

A survey on stimulatory effects of topical application of radioactive lantern mantle powder on wound healing

Background: Poorly educated people in some parts of Iran use burned mantles as a wound healing medicine. Materials and Methods: To perform surface area measurement, twenty rats were divided randomly into two groups of 10 animals each. The first group received topical burned radioactive lantern mantle powder on the first to third days after making excision wounds. The second group rece...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical sciences

جلد ۷، شماره ۱، صفحات ۴۳-۴۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023